Dopamine pathway induces emergence from anesthesia
نویسندگان
چکیده
منابع مشابه
Methylphenidate actively induces emergence from general anesthesia.
BACKGROUND Although accumulating evidence suggests that arousal pathways in the brain play important roles in emergence from general anesthesia, the roles of monoaminergic arousal circuits are unclear. In this study, the authors tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane general anesthesia. METHODS Us...
متن کاملActivation of D1 dopamine receptors induces emergence from isoflurane general anesthesia.
BACKGROUND A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia. METHODS In adult rats, we tested the effects of chloro-APB (D1 agonist) an...
متن کاملDopamine-enhancing medications to accelerate emergence from general anesthesia.
5 January 2013 D OPAMINERGIC neurotransmission is prominently implicated in emergence from the minimal conscious state,1,2 general anesthesia,3 and in sleep–wake regulation.4 The molecular mechanisms for these effects are still incompletely understood. The anatomical and neurochemical signatures of the dopamine (DA) system for arousal under conditions of general anesthesia are clinically import...
متن کاملDextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence
Methylphenidate induces reanimation (active emergence) from general anesthesia in rodents, and recent evidence suggests that dopaminergic neurotransmission is important in producing this effect. Dextroamphetamine causes the direct release of dopamine and norepinephrine, whereas atomoxetine is a selective reuptake inhibitor for norepinephrine. Like methylphenidate, both drugs are prescribed to t...
متن کاملResidual paralysis after emergence from anesthesia.
SEVERAL studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU), even with the administration of acetylcholinesterase inhibitors. The frequency of this phenomenon, which has been called “residual curarization,” “residual neuromuscular block,” “postoperative residual curarization,” or “residual paralysis,” ranges between 4 and 50% depending on the d...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2014
ISSN: 0093-7355,1548-4475
DOI: 10.1038/laban.619